Keren M, Keren N, Eden A, Tsangen S, Weizman A, Zalsman G. The complex impact of five years of stress related to life-threatening events on pregnancy outcomes: a preliminary retrospective study. Eur Psychiatry. 2015 Feb;30(2):317-21. PubMed PMID: 25498241.
Eur Psychiatry. 2015 Feb;30(2):317-21. doi: 10.1016/j.eurpsy.2014.10.004. Epub 2014 Dec 12.
The complex impact of five years of stress related to life-threatening events on pregnancy outcomes: a preliminary retrospective study.
Keren M(1), Keren N(2), Eden A(3), Tsangen S(3), Weizman A(4), Zalsman G(5).
OBJECTIVE: To study the impact of chronic, life-threatening stressors in the form of daily missile attacks, for five consecutive years, on pregnancy outcomes.
METHOD: Charts of deliveries from two neighboring towns in the south of Israel, covering the years 2000 and 2003-2008, were reviewed retrospectively. One city had been exposed to missile attacks, while the other was not. For each year, 100 charts were chosen at random.
RESULTS: Significant association was found between exposure to stress and frequency of pregnancy complications (P=0.047) and premature membrane rupture (P=0.029). A more detailed analysis, based on dividing the stressful years into three distinct periods: early (2003-2004), intermediate (2005-2006) and late (2007-2008), revealed that preterm deliveries were significantly more frequent (P=0.044) during the intermediate period, as was premature membrane rupture during the late period (P=0.014).
CONCLUSION: Exposure to chronic life-threatening stress resulted in more pregnancy complications and in particular more premature membrane ruptures. The impact was most significant during the middle period of the 5-year-exposure to the stressor. Hence it seems that factors of duration and habituation may play a role in the impact of chronic, life-threatening stressors on pregnancy.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.
PMID: 25498241 [PubMed - in process]